Figure 3.

Enzyme-linked immunosorbent assay (ELISA) analysis of MMP-3 (A) and -9 (B) expressions in serum. The blood samples were centrifuged for serum preparation and cryopreserved at −80 °C until analysis. Serum MMP-3 and -9 were measured by ELISA. Bar graphs describe the expression as mean ± SEM (standard error of the mean); n = 2–3 dogs per group. Note that significant difference between MA-ECM containing groups and non-containing groups. Student t-test with Bonferroni correction for multiple comparisons. * p < 0.05, ** p < 0.01, *** p < 0.001.