Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of the DAMPs activating the RAGE pathway. The receptor for advanced glycation end-products (RAGE) is a multi-ligand protein that integrates the immunoglobulin superfamily of receptors. RAGE recognizes a variety of DAMPs including S100, high mobility group box 1 protein (HMGB1), Amyloid beta (Aβ), and transcription factor A mitochondrial (TFAM). RAGE activation leads to downstream NFκB signaling and transcription of inflammatory factors.
