Table 12.
DAMPs as therapeutic agents.
| Retinal Disorders | DAMPs | Therapeutic Property |
Signaling Pathway |
Refs |
|---|---|---|---|---|
| Endophthalmitis | Cathelicidin | Anti-microbial | TLRs | [26] |
| Uveitis | IL-33 | Anti-inflammatory | Macrophage M2 polarization |
[45] |
| Glaucoma | Decorin | Anti-fibrotic | Inhibits TGF-β | [286] |
| Diabetic retinopathy |
LIF HS |
Anti-angiogenic Anti-angiogenic |
HIF-1α and VEGF Inhibiting VEGF-VEGFR2 binding |
[116,288] |
| AMD | LIF | Anti-angiogenic | STAT3 pathway | [210] |
| HSP70 | Anti-inflammatory | TLR2/TLR4 | [213,214] | |
| IL-33 | Anti-angiogenic | Not known | [289] |