Table 1.
Enriched gene sets of the MSigDB Hallmark collection for OB versus AD, OB versus MSC, and AD versus MSC. (Log2FC, logarithm of fold change; Meta-q, meta q-value used statistical methods; Avg. Expr., average expression).
| Gene set | Log2FC OB vs. AD | Meta-q | Avg. Expr. OB | Avg. Expr. AD |
|---|---|---|---|---|
| MYC_TARGETS_V1 | 0.575 | 0.0005 | 6.103 | 5.528 |
| E2F_TARGETS | 0.410 | 0.0005 | 7.049 | 6.638 |
| G2M_CHECKPOINT | 0.278 | 0.0005 | 5.411 | 5.133 |
| PEROXISOME | −0.223 | 0.0366 | 6.925 | 7.148 |
| BILE_ACID_METABOLISM | −0.317 | 0.0006 | 6.762 | 7.079 |
| FATTY_ACID_METABOLISM | −0.350 | 0.0006 | 6.535 | 6.885 |
| CHOLESTEROL_HOMEOSTASIS | −0.377 | 0.0315 | 6.318 | 6.695 |
| OXIDATIVE_PHOSPHORYLATION | −0.438 | 0.0006 | 5.028 | 5.466 |
| ADIPOGENESIS | −0.491 | 0.0006 | 5.782 | 6.273 |
| Gene set | Log2FC OB vs. MSC | Meta-q | Avg. Expr. OB | Avg. Expr. MSC |
| MYC_TARGETS_V2 | 0.279 | 0.0435 | 5.745 | 5.466 |
| E2F_TARGETS | 0.274 | 0.0008 | 7.034 | 6.76 |
| MYC_TARGETS_V1 | 0.241 | 0.0098 | 6.076 | 5.835 |
| Gene set | Log2FC AD vs. MSC | Meta-q | Avg. Expr. AD | Avg. Expr. MSC |
| OXIDATIVE_PHOSPHORYLATION | 0.659 | 0.0006 | 5.590 | 4.931 |
| CHOLESTEROL_HOMEOSTASIS | 0.533 | 0.0006 | 6.654 | 6.121 |
| ADIPOGENESIS | 0.529 | 0.0006 | 6.206 | 5.677 |
| FATTY_ACID_METABOLISM | 0.478 | 0.0006 | 6.909 | 6.431 |
| BILE_ACID_METABOLISM | 0.411 | 0.0006 | 7.096 | 6.685 |
| PEROXISOME | 0.337 | 0.0028 | 7.282 | 6.945 |
| XENOBIOTIC_METABOLISM | 0.271 | 0.0011 | 5.857 | 5.585 |
| PI3K_AKT_MTOR_SIGNALING | −0.203 | 0.0359 | 7.127 | 7.331 |
| MYC_TARGETS_V1 | −0.334 | 0.0105 | 5.605 | 5.939 |
| MITOTIC_SPINDLE | −0.335 | 0.0006 | 6.635 | 6.97 |