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. 2022 Feb 27;23(5):2625. doi: 10.3390/ijms23052625

Figure 4.

Figure 4

Remodulation of the gut–brain axis through non-pharmaceutical approaches. (a) Intake of prebiotics (non-digestible fiber) modulate gut microbial diversity at a limited scale. (b) Bi-directional relationship of polyphenols and gut microbiota: i. polyphenols affect the growth and metabolism of gut microbiota and modulate their composition and function, ii. gut microbiota metabolizes specific polyphenols and converts them into bioactive compounds with health benefits. (c) Use of prebiotics and polyphenols together could be a powerful strategy for in situ reprogramming of gut microbiota to treat SCZ.