A 36-year-old man with a history of metastatic melanoma treated with 40 Gy of whole-brain radiation therapy and a partial brain boost of 10 Gy presented with headache, seizure, visual disturbance, and speech impairment. A and B, Cortical edematous changes with gyriform enhancement is seen in the left temporal and occipital lobes. C, SWI shows no convincing focal WM hypointensity. D and E, DWI and ADC show no restricted diffusion. He completely recovered.