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Pathway by which aldehyde dehydrogenase 2 (ALDH2) catalyzes aldehyde metabolism in ethanol metabolism. ALDH2 metabolizes acetaldehyde into acetate, metabolizes the malondialdehyde (MDA) into malonic acid (MOA) or acetaldehyde, and metabolizes the 4-hydroxy-2-nonenal (4-NHE) to generate 4-hydroxy-2-nonenoic acid (NHA) to reduce the accumulation of toxic aldehydes produced during metabolism. CHOL = cholesterol; FA = fatty acids; KB = ketone bodies.
