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. 2022 Feb 28;23(5):2721. doi: 10.3390/ijms23052721
AF annulus fibrosus
BDNF brain-derived neurotrophic factor
CCL2 C-C motif chemokine ligand 2
CEP cartilage endplate
CLBP chronic low back pain
CXCL5 C-X-C motif chemokine ligand 5
DD disc degeneration
DDD degenerative disc disease
ECM extracellular matrix
EGF epidermal growth factor
GDF-7 growth differentiation factor-7
GM-CSF granulocyte-macrophage colony-stimulating factor
ICAM-1 intercellular adhesion molecule-1
IDO indoleamine 2,3 dioxygenase
IFN-γ interferon-gamma
IGF-1 insulin-like growth factor-1
IL-1α interleukin-1 alpha
IL-1β interleukin-1 beta
IL-6 interleukin-6
IL-8 interleukin-8
IL-17 interleukin-17
IVD intervertebral disc
IVDC intervertebral disc cell
LBP low back pain
MC Modic changes
MC1 Modic type 1 changes
MC2 Modic type 2 changes
MC3 Modic type 3 changes
M-CSF macrophage colony-stimulating factor
MRI magnetic resonance imaging
MSC mesenchymal stem cell
NGF nerve growth factor
NO nitric oxide
NP nucleus pulposus
NPC nucleus pulposus cell
NTRK1 neurotrophic receptor tyrosine kinase 1
OPG osteoprotegerin
OP-1 osteogenic protein-1
OSCAR osteoclast associated Ig-like receptor
PGE2 prostaglandin E2
PRP platelet-rich plasma
RANKL tumor necrosis superfamily member 11
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
TGF-β transforming growth factor-beta
TNF-α tumor necrosis factor-alpha
TrkA neurotrophic receptor tyrosine kinase 1
TSG-6 tumor necrosis factor-alpha-inducible protein 6
VEGF vascular endothelial growth factor
ZA zoledronic acid