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. 2022 Mar 2;23(5):2757. doi: 10.3390/ijms23052757

Figure 4.

Figure 4

Evaluation of the effect of THC treatment on improving the spatial reference memory of 14-month-old APP/PS1 mice using the RAWM test. Individual mice were subjected to five trials per day for 15 consecutive days with each block containing 15 trials. (A) No significant difference in latency between male and female mice within individual study groups in Trial 5 of Block 5 (p = 0.998, p = 0.996, p = 0.998, and p = 0.996 for NTG, TG, 0.02 mg/kg, and 0.2 mg/kg THC groups, respectively, using the Independent sample t test). (B) No significant difference in number of errors between male and female mice within individual study groups in Trial 5 of Block 5 (p = 0.992, p = 0.979, p = 0.992, and p = 0.992 for NTG, TG, 0.02 mg/kg, and 0.2 mg/kg THC groups, respectively, using the Independent sample t test). (C) Significant decrease in the latency in NTG control (p < 0.001), 0.02 mg/kg THC (p < 0.01, and 0.2 mg/kg THC (p < 0.001) groups compared with the TG control group in Block 5 Trial 5. Significant decrease in latency was also found in the NTG control (p < 0.001) and 0.2 mg/kg THC (p < 0.05) groups compared to the TG control group in Block 4 Trial 5. (D) Significant decrease in the number of errors in 0.02 mg/kg THC (p < 0.01) and 0.2 mg/kg THC (p < 0.001) groups compared with the TG control group in Block 5 Trial 5. Significant decrease in the number of errors was also found in the NTG control (p < 0.001) and 0.2 mg/kg THC (p < 0.01) groups compared with the TG control group in Block 4 Trial 5. Data are expressed as mean ± SD. SD is denoted by the error bars. Comparison of mean latency and number of errors between female and male animals in individual study groups was made by multiple t-tests with correction for multiple comparisons using the Holm–Sidak method. Comparison of mean latency and number of errors among different study groups were made using one-way ANOVA with post hoc Bonferroni’s multiple comparisons test. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared between the control NTG (N = 7), control TG (N = 6), 0.02 mg/kg THC (N = 8), and 0.2 mg/kg THC (N = 6) groups.