Skip to main content
. 2022 Mar 2;23(5):2757. doi: 10.3390/ijms23052757

Figure 8.

Figure 8

Immunohistochemical (IHC) analysis of molecular markers associated with the neuropathologic change in AD. (A) Representative IHC images for p-Tau, Iba-1, NeuN, CB1, and GSK3β in brain sections. (B) Quantification of IHC staining of for p-Tau, Iba-1, NeuN, CB1, and GSK3β in brain sections. No statistically significant difference in the expression of phospho-Tau, Iba1, CB1, and GSK-3β and the NeuN area was observed between the vehicle and THC treatment in APP/PS1 mice, suggesting the limited effect of THC on reversing the neuropathologic change in AD. Data are expressed as mean ± SD (N = 7 for the control NTG group, N = 6 for the control TG and 0.2 mg/kg THC groups, and N = 8 for the 0.02 mg/kg THC group). SD is denoted by the error bars. * p < 0.05 and ** p < 0.01 compared between the control NTG mice, control APP/PS1 mice, and APP/PS1 mice treatment with 0.02 and 0.2 mg/kg THC using one-way ANOVA followed by the Tukey–Kramer post hoc multiple comparison test.