Table 1.

Characteristics of colorectal carcinomas classified according to SPATA18 expression.

			SPATA18
	Total No.		High		Low		p-Value
	268	(100%)	193	(72%)	75	(28%)
Sex								a
Male	143	[53%]	106	[55%]	37	[49%]	0.49
Female	125	[47%]	87	[45%]	38	[51%]
Age, years (mean ± S.D.)	68.6 ± 12.6		68.3 ± 12.3		69.1 ± 13.3		0.63	b
Size, cm (mean ± S.D.)	5.0 ± 2.6		4.62 ± 2.29		5.98 ± 2.96		<0.0001	b
Tumor location								a
Right-sided colon	123	[46%]	87	[45%]	36	[48%]	0.91
Left-sided colon	86	[32%]	63	[33%]	23	[31%]
Rectum	59	[22%]	43	[22%]	16	[21%]
pT stage								c
pT2	36	[13%]	32	[17%]	4	[6%]	0.036
pT3	188	[70%]	136	[70%]	52	[69%]
pT4	44	[16%]	25	[13%]	19	[25%]
Histological differentiation								a
Well to moderately	241	[90%]	181	[94%]	60	[80%]	0.0017
Poorly	27	[10%]	12	[6%]	15	[20%]
Mucus production								d
Positive	14	[5%]	11	[6%]	3	[4%]	0.76
Negative	254	[95%]	182	[94%]	72	[96%]
Lymph node metastasis								a
Positive	99	[39%]	77	[42%]	22	[32%]	0.00039
Negative	153	[61%]	106	[58%]	47	[68%]
Peritoneal metastasis								a
Positive	50	[19%]	33	[17%]	17	[23%]	0.38
Negative	218	[81%]	160	[83%]	58	[77%]
Distant organ metastasis								a
Positive	44	[16%]	30	[16%]	14	[19%]	0.66
Negative	224	[84%]	163	[84%]	61	[81%]
Operation status								a
Complete resection	236	[88%]	175	[91%]	61	[81%]	0.057
Incomplete resection	32	[12%]	18	[9%]	14	[19%]
MMR system status								a
Deficient	238	[88%]	173	[90%]	65	[87%]	0.63
Preserved	30	[12%]	20	[10%]	10	[13%]

a, p-values were calculated by the chi-squared test for SPATA18 expression. b, t-test, c, Cochran-Armitage trend, or d, Fisher’s exact test was used to calculate p-values. The Bonferroni-corrected p-value for significance was p ≈ 0.0042 (0.05/12).