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. 2022 Mar 2;23(5):2766. doi: 10.3390/ijms23052766

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Preparation of fentanyl-based MOR/I₂-IBS ligands. See Figure 3 and Table 1 for particular representatives. In red marked are fragments characteristic for I₂-IBS ligands. Boc—tert-butyloxycarbonyl, Cbz—carboxybenzyl.