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. 2022 Mar 5;23(5):2853. doi: 10.3390/ijms23052853

Table 1.

P-SH and S-thiolated proteins in the plasma or serum of patients with moderate-to-severe stages of CKD. All of the data are expressed as means ± SD, unless otherwise indicated. (a) Median, with interquartile range in parentheses. The data of S-thiolated proteins are in grey cells. *** p < 0.001, ** p < 0.01, * p < 0.05.

Concentration Albumin Concentration mg/dL Additional Information Reference
CKD Patients Control Group CKD Patients Control Group
202 ± 20 μM (n = 10) 279 ± 12 μM (n = 10) - - CKD patients not receiving renal replacement therapy [77]
182.3 ± 15.9 μg/L (n = 24) *** 286.4 ± 21.8 μg/L
(n = 20)
- - albumin
significantly lower in CKD patients compared to healthy controls (p < 0.0001)
Analyses performed in serum
[78]
304.0 ± 55.2 μM
(n = 184) ***
328.4 ± 33.3 μM
(n = 43)
4.3 ± 0.38 4.4 ± 0.22 CKD patients at stages 3, 4 [79]
191.26 ± 16.75 μM
(n = 41) **
342.34 ± 43.43 μM
(n = 41)
2.1 ± 1.0 4.4 ± 1.3 CKD patients on conservative treatment
Analyses performed in serum
[80]
6.3 ± 0.9 μmol/g protein
(n = 16) *
7.3 ± 0.8 μmol/g protein
(n = 13)
- - Non dialysis CKD patients [81]
3.59 (3.31–4.80) μmol/g protein (a)
(n = 24)
- - - CKD hypertensive patients stages 3, 4 [82]
stage 2: 9.8 ± 3.5 nmol/mg albumin
stage 3: 9.9 ± 2.6 nmol/mg albumin
stages 5: 7.9 ± 2.5 nmol/mg albumin
(n = 68)
- - - - [83]
69.44 ± 7.26%
(n = 55)
- 4.1 ± 0.4 - Predialysis patients with CKD [84]
28.59 ± 6.93% S-thiolated albumin
stages 1, 2
77.2 ± 3.4% (n = 7)
stage 3a
75.5 ± 3.8%
(n = 7)
stage 3b
71.5 ± 3.3% (n = 6)
stages 4, 5
66.2 ± 4.1%
(n = 12)
- stages 1, 2
4.0 ± 0.1
stage 3a
4.0 ± 0.1
stage 3b
4.1 ± 0.3
stages 4, 5
4.1 ± 0.3
- [85]
stages 1, 2
21.0 ± 3.4% (n = 7)
stage 3a
22.4 ± 4.1% (n = 7)
stage 3b
26.2 ± 3.1%
(n = 6)
stages 4, 5
31.1 ± 4.1% (n = 12)
S-thiolated albumin
633 ± 248 nM 430 ± 153 nM S-cysteinylated + S-homocysteinylated LDL
Analyses carried out by capillary electrophoresis laser-induced fluorescence detection
[86]