Table 3.
Outcomes in <28 weeks gestational age according to interval between doses of antenatal corticosteroids.
| CM N = 94 |
AM N = 19 |
OR (CI 95%) Unadjusted |
p * | OR (CI 95%) Adjusted |
p † Adjusted |
|
|---|---|---|---|---|---|---|
| Serious outcome | 70 (74.5%) | 13 (68.4%) | 0.7 (0.2–2.1) | 0.58 | ||
| Neonatal death | 26 (27.7%) | 3 (15.8%) | 0.4 (0.1–1.8) | 0.32 | ||
| Intubation at birth | 86 (91.5%) | 18 (94.7%) | 1.6 (0.1–14.2) | 0.99 | ||
| Apgar < 5 at 5 min | 11 (11.7%) | 1 (5.3%) | 0.4 (0.05–3.4) | 0.41 | ||
| Severe IVH | 16 (17%) | 3 (15.8%) | 0.9 (0.2–3.5) | 0.89 | ||
| PVL | 7 (7.4%) | 0 | 0.6 (0.3–1.3) | 0.59 | ||
| NEC > 2 | - | - | - | - | ||
| Intestinal perforation | 11 (11.7%) | 0 | 0.4 (0.2–0.8) | 0.01 | NA | |
| Treated ROP | 27 (28.7%) | 4 (21.1%) | 0.6 (0.2–2.1) | 0.49 | ||
| Hypotension 1 week | 49 (52.1%) | 3 (16.7%) | 0.1 (0.05–0.6) | 0.009 | 0.2 (0.05–1) | 0.06 |
| Treated PDA | 18 (19.1%) | 6 (31.6%) | 1.9 (0.6–5.8) | 0.22 | ||
| Early sepsis | 11 (11.7%) | 2 (11.1%) | 0.9 (0.1–4.6) | 0.99 | ||
| Late sepsis | 61 (64.9%) | 11 (61.1%) | 0.8 (0.3–2.4) | 0.75 | ||
| BPD | 41 (56.2%) | 7 (43.8%) | 0.6 (0.2–1.8) | 0.36 | ||
| Need for surfactant | 85 (90.4%) | 17 (89.5%) | 0.9 (0.1–4.5) | 0.89 | ||
| Need for MV | 68 (72.3%) | 12 (63.2%) | 0.6 (0.2–1.8) | 0.42 | ||
| Maximum FiO2 | 62.2 ± 3.4 | 44.4 ± 7.2 | 0.03 | 0.04 | ||
| MV time (hours) | 477.8 ± 82.4 | 203.1 ± 51.6 | 0.006 | 0.14 |
Qualitative variables are expressed as n (%) within each cohort, quantitative variables such as mean ± standard deviation. * Chi–square, Fisher’s exact test, Student’s t-test. † Results of multivariate analyses are shown for significant variables in the unadjusted model. vIVH: intraventricular haemorrhage; PVL: periventricular leukomalacia; NEC: necrotising enterocolitis; ROP: retinopathy of prematurity; PDA: patent ductus arteriosus; BPD: bronchopulmonary dysplasia; MV: mechanical ventilation. NA: not applicable. CM: complete maturation; AM: advanced maturation.