Table 1.
Comparisons of clinical parameters in subjects with and without significant liver fibrosis.
| Significant Liver Fibrosis | |||
|---|---|---|---|
| No | Yes | ||
| N = 11,181 | N = 509 | p Value | |
| Age, years | 48.0 ± 12.6 | 53.2 ± 14.0 | <0.001 |
| Age ≥ 65 years | 1028 (9.2%) | 113 (22.2%) | <0.001 |
| Male | 6414 (57.4%) | 371 (72.9%) | <0.001 |
| BMI, kg/m2 | 24.1 ± 3.5 | 26.1 ± 4.1 | <0.001 |
| Obesity (BMI ≥ 27 kg/m2) | 2066 (18.5%) | 187 (36.7%) | <0.001 |
| Systolic BP, mmHg | 117.0 ± 17.0 | 127.3 ± 18.9 | <0.001 |
| Diastolic BP, mmHg | 69.2 ± 10.8 | 74.9 ± 12.0 | <0.001 |
| Hypertension | 1843 (16.5%) | 164 (32.2%) | <0.001 |
| Cholesterol, mg/dL | 198.1 ± 37.1 | 201.4 ± 38.8 | 0.056 |
| Cholesterol ≥ 200 mg/dL | 5059 (45.2%) | 277 (54.4%) | <0.001 |
| Triglyceride, mg/dL | 129.8 ± 90.9 | 175.4 ± 141.7 | <0.001 |
| Triglyceride ≥ 150 mg/dL | 3048 (27.3 %) | 225 (44.2%) | <0.001 |
| HDL-C, mg/dL | 49.6 ± 13.6 | 45.6 ± 14.9 | <0.001 |
| FPG, mg/dL | 90.8 ± 17.3 | 100.4 ± 31.4 | <0.001 |
| 2 h PG, mg/dL | 122.2 ± 51.3 | 158.6 ± 79.2 | <0.001 |
| Hba1c, % | 5.6 ± 0.7 | 6.0 ± 1.2 | <0.001 |
| Diabetes mellitus | 930 (8.3%) | 115 (22.6%) | <0.001 |
| Creatinine, mg/dL | 0.88 ± 0.38 | 0.94 ± 0.46 | 0.004 |
| ALT, U/L | 27.2 ± 16.5 | 81.0 ± 58.2 | <0.001 |
| AST, U/L | 23.5 ± 7.0 | 58.6 ± 42.8 | <0.001 |
| Uric acid, mg/dL | 6.0 ± 1.5 | 6.7 ± 1.7 | <0.001 |
| Hyperuricemia | 3164 (28.3%) | 235 (46.2%) | <0.001 |
| Platelet, 103/μL | 255.8 ± 58.8 | 195.9 ± 59.4 | <0.001 |
| NAFLD | 7318 (34.5%) | 336 (66.0%) | <0.001 |
| APRI | 0.28 ± 0.17 | 1.07 ± 1.15 | <0.001 |
| Total bilirubin, mg/dL | 0.8 ± 0.4 | 1.0 ± 0.6 | <0.001 |
| Albumin, g/dL | 4.4 ± 0.3 | 4.4 ± 0.4 | 0.314 |
| Alkaline Phosphatase, U/L | 63.3 ± 19.6 | 71.3 ± 26.7 | <0.001 |
| Current smoking | 1211 (10.8 %) | 64 (12.6%) | 0.215 |
| Current drinking | 1235 (11.0 %) | 69 (13.6 %) | 0.081 |
| Habitual exercise | 909 (8.1%) | 31 (6.1%) | 0.117 |
Data are presented as the mean ± standard deviation or numbers (percent); BMI: body mass index; BP: blood pressure; HDL-C: high-density lipoprotein-cholesterol; FPG: fasting plasma glucose; 2 h PG: 2 h plasma glucose; A1C: glycated hemoglobin; ALT: alanine aminotransferase; AST: aspartate transaminase; NAFLD: non-alcoholic fatty liver disease; APRI: the AST to Platelet Ratio Index, calculated as AST/40/Platelet (103/μL) ∗ 100.