Table 3.
Cox regression analysis of AACS for the secondary outcomes.
| AACS | Events, n (%) | Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CIs) |
p Value | HR (95% CIs) |
p Value | HR (95% CIs) |
p Value | HR (95% CIs) |
p Value | |||
| Fatal and non-fatal CV event | 0 | 72 (5.3) | Reference | Reference | Reference | Reference | ||||
| 1–2 | 39 (11.2) | 2.149 (1.384, 3.337) |
<0.001 | 1.555 (1.036, 2.333) |
0.033 | 1.357 (0.875, 2.103) |
0.176 | 1.372 (0.867, 2.169) |
0.177 | |
| 3–4 | 20 (12.0) | 2.129 (1.213, 3.738) |
0.009 | 1.246 (0.741, 2.095) |
0.408 | 1.087 (0.615, 1.922) |
0.773 | 1.114 (0.620, 2.001) |
0.719 | |
| 5–6 | 12 (13.0) | 2.440 (1.214, 4.906) |
0.012 | 1.123 (0.587, 2.147) |
0.725 | 0.873 (0.419, 1.819) |
0.717 | 0.950 (0.447, 2.018) |
0.893 | |
| ≥7 | 24 (19.7) | 4.941 (3.039,8.035) | <0.001 | 1.733 (1.037, 2.896) |
0.036 | 1.806 (1.061, 3.075) |
0.029 | 1.052 (1.030, 1.073) |
<0.001 | |
| All-cause death | 0 | 57 (4.2) | Reference | Reference | Reference | Reference | ||||
| 1–2 | 19 (5.5) | 1.512 (0.863, 2.648) |
0.149 | 0.790 (0.460, 1.357) |
0.393 | 0.727 (0.403, 1.311) |
0.290 | 0.746 (0.413, 1.346) |
0.330 | |
| 3–4 | 15 (9.0) | 1.749 (0.889, 3.441) |
0.106 | 0.955 (0.522, 1.747) |
0.882 | 0.763 (0.388, 1.503) |
0.435 | 0.751 (0.370, 1.523) |
0.427 | |
| 5–6 | 14 (15.2) | 4.011 (2.139,7.522) |
< 0.001 | 1.272 (0.670, 2.416) |
0.462 | 1.076 (0.533, 2.171) |
0.839 | 1.219 (0.595, 2.499) |
0.589 | |
| ≥7 | 24 (19.7) | 5.600 (3.338, 9.395) |
< 0.001 | 1.703 (1.005, 2.885) |
0.048 | 1.826 (1.039, 3.208) |
0.036 | 1.949 (1.073, 3.539) |
0.028 | |
Model 1, unadjusted model. Model 2, model 1 + adjusted for age, sex, Charlson comorbidity index, primary renal disease, current smoking status, medication (ACEi/ARBs, diuretics, number of anti-HTN drugs, statins), BMI, and SBP. Model 3, model 2 + adjusted for hemoglobin, albumin, fasting glucose, HDL-C, TG, 25(OH) vitamin D, hs-CRP, GFR and spot urine ACR. Model 4, model 3 + adjusted for LVEF and categorized E/e’ at the baseline. Abbreviations: AACS, abdominal aortic calcification score; CI, confidence interval; CV, cardiovascular; HR, hazard ratio.