Table 2.
Associations between maternal body composition and human milk bacterial OTU relative abundance.
Maternal Predictor | Secretor | Non-Secretor | Interaction | ||||
---|---|---|---|---|---|---|---|
Parameter Estimate | SE | p-Value | Parameter Estimate | SE | p-Value | p-Value | |
OTU03 (Streptococcus salivarius) | |||||||
Log (Weight (kg)) | −2.24 | 0.82 | 0.01 | 6.01 | 5.07 | 0.24 | 0.12 |
Log (BMI (kg/m2)) | −2.52 | 0.89 | 0.01 | 4.44 | 2.8 | 0.12 | 0.02 |
Log (FM (kg)) | −1.37 | 0.5 | 0.01 | 2.63 | 2 | 0.19 | 0.06 |
FM (%) | −0.06 | 0.03 | 0.04 | 0.12 | 0.08 | 0.17 | 0.05 |
Log (FMI (kg/m2)) | −1.42 | 0.52 | 0.01 | 2.25 | 1.51 | 0.14 | 0.02 |
Log (FM/FFM) | −1.33 | 0.64 | 0.04 | 2.66 | 1.96 | 0.18 | 0.06 |
OTU06 (Streptococcus lactarius) | |||||||
Age | 0.03 | 0.04 | 0.41 | 0.82 | 0.26 | <0.001 | <0.001 |
OTU08 (Gemella haemolysans) | |||||||
Log (BMI (kg/m2)) | −0.69 | 1.28 | 0.59 | 5.43 | 2.39 | 0.03 | 0.03 |
FFMI (kg/m2) | −0.05 | 0.11 | 0.64 | 0.55 | 0.24 | 0.03 | 0.03 |
Log (FMI (kg/m2)) | −0.37 | 0.74 | 0.62 | 2.62 | 1.22 | 0.04 | 0.04 |
OTU10 (Veillonella nakazawae) | |||||||
FFMI (kg/m2) | 0.12 | 0.06 | 0.04 | 0.42 | 0.19 | 0.03 | 0.14 |
Entire cohort | |||||||
OUT01 (Streptococcus mitis) | |||||||
Age | 0.07 | 0.03 | 0.04 | - | - | - | - |
OTU02 (Staphylococcus epidermidis) | |||||||
Log (Weight (kg)) | −1.54 | 0.69 | 0.03 | - | - | - | - |
FFM (kg) | −0.04 | 0.02 | 0.02 | - | - | - | - |
Log (FM (kg)) | −1.04 | 0.43 | 0.02 | - | - | - | - |
Log (FMI (kg/m2)) | −0.9 | 0.43 | 0.04 | - | - | - | - |
OTU10 (Veillonella nakazawae) | |||||||
FFM (kg) | 0.04 | 0.02 | 0.03 | - | - | - | - |
Data are parameter value ± standard error of measurement (SE); note that these estimates are on the logit scale. When the interaction term with secretor status was present in the final model, results were separated by secretor and non-secretor groups, whereas when the interaction term was not present in the final model, results were presented for the entire cohort. Significant p-values are indicated by the bold text. BMI—body mass index; ECS—emergency caesarean section; FFM—fat-free mass; FFMI—fat-free mass index; FM—fat mass; FM/FFM—fat mass to fat-free mass ratio; FMI—fat mass index; MOD—mode of delivery.