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. 2022 Mar 3;23(5):2800. doi: 10.3390/ijms23052800

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the major NR signaling pathways affecting erythropoiesis and of their role in erythroid cell lineage specification and maturation. EHT: endothelial hematopoietic transition; HSC: hematopoietic stem cell; MMP: multiple myeloid progenitor; BFU-E: blast-forming unit, erythroid; CFU-E: colony-forming unit, erythroid; Pro Er: proerythroblast; MPPS: splenic multipotent progenitors; RA: retinoic acid; ER: estrogen receptor; AR: androgen receptor; GR: glucocorticoid receptor; GR: granulocytes; VDR: vitamin D receptor; PPARα: peroxisome proliferator-activated receptor; v-ErbA: mutated version of thyroid hormone receptor-α, responsible for avian erythroblastosis; T3: triiodothyronine; TR2/4: testicular receptors 2/4; COUP-TFII: chicken ovalbumin upstream promoter transcription factor II.