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The PRGF-mediated gene induction of SEMA7A, MMP-2, ANGPLT4 and IL-32 in human keratinocytes is transduced via the IL-6 receptor. Human primary keratinocytes were stimulated for 24 h with PRGF (1:10) in the presence or absence of the IL-6-receptor blocking antibody tocilizumab 50 µg/mL). Relative gene expression was analyzed by real-time PCR. Shown are means ± s.e.m of three stimulations (* p < 0.05, ** p < 0.01; ns = non-significant, Student’s t-test).
