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. Author manuscript; available in PMC: 2023 Feb 18.
Published in final edited form as: Circ Res. 2022 Feb 17;130(4):529–551. doi: 10.1161/CIRCRESAHA.121.319892

Figure 4. Stratified Medical Therapy Using Invasive Coronary Function Testing in INOCA.

Figure 4.

The Coronary Microvascular Angina (CorMicA) Trial randomized patients with angina and no obstructive CAD to invasive coronary function testing linked to stratified medical therapy or standard care. Invasive coronary function testing included assessment of coronary flow reserve (CFR), index of microcirculatory resistance (IMR), fractional flow reserve (FFR), and vasoreactivity testing with acetylcholine (Ach) and nitroglycerin (GTN). Stratified medical therapy based on diagnosis of microvascular angina, vasospastic angina, vs noncardiac chest pain was associated with improved angina and quality of life. Reprinted from Ford TJ et al46 with permission.