Table 1.
Patients’ characteristics.
| Fast Metabolizers n = 58 |
Slow Metabolizers n = 22 |
p-Value | |
|---|---|---|---|
| age (years) | 50.0 ± 16.1 | 49.8 ± 14.7 | 0.957 a |
| sex (m/f), n (%) | 37 (63.8%)/21 (36.2%) | 13 (59.1%)/9 (40.9%) | 0.797 b |
| weight (kg) | 80.8 ± 18.3 | 76.4 ± 15.1 | 0.274 a |
| height (m) | 1.77 ± 0.09 | 1.75 ± 0.09 | 0.267 a |
| BMI (kg/m²) | 25.5 ± 5.3 | 24.9 ± 4.3 | 0.570 a |
| living donor transplantation | 37 (63.8%) | 16 (72.7%) | 0.598 b |
| ABO-i | 13 (22.4%) | 7 (31.8%) | 0.399 b |
| ESP transplantation | 4 (6.9%) | 1 (4.5%) | 1 b |
| DGF | 6 (10.3%) | 3 (13.6%) | 0.700 b |
| cold ischemic time (h) | 7.4 ± 5.0 | 6.7 ± 4.3 | 0.539 a |
| warm ischemic time (min) | 35.9 ± 8.3 | 35.9 ± 9.2 | 0.968 a |
| Number of Transplantations | |||
| 1 | 51 (87.9%) | 19 (86.4%) | 0.785 b |
| 2 | 6 (10.3%) | 3 (13.6%) | |
| 3 | 1 (1.7%) | 0 | |
| HLA MM | |||
| 0 | 13 (22.4%) | 8 (36.4%) | 0.462 b |
| 1–3 | 23 (39.7%) | 7 (31.8%) | |
| 4–6 | 22 (37.9%) | 7 (31.8%) | |
| PRA > 20% | 5 (8.6%) | 2 (9.1%) | 1 b |
| CMV risk status | |||
| low | 13 (22.4%) | 2 (9.1%) | 0.105 b |
| intermediate | 34 (58.6%) | 11(50.0%) | |
| high | 11 (19.0%) | 9 (40.9%) | |
| Donor Characteristics | |||
| donor age (years) | 52.7 ± 12.2 | 55.8 ± 9.7 | 0.246 a |
| donor sex (m/f), n (%) | 24 (41.4%)/34 (58.6%) | 7 (31.8%)/15 (68.2%) | 0.608 b |
| Diagnosis of ESRD | |||
| benign nephrosclerosis | 4 (6.9%) | 1 (4.5%) | 0.345 b |
| diabetic nephropathy | 3 (5.2%) | 1 (4.5%) | |
| glomerulonephritis | 31 (53.4%) | 14 (63.6%) | |
| chronic pyelonephritis | 0 | 1 (4.5%) | |
| cystic nephropathy | 14 (24.1%) | 2 (9.1%) | |
| Alport syndrome | 1 (1.7%) | 0 | |
| Mediterranean fever | 0 | 1 (4.5%) | |
| congenital renal dysgenesis | 4 (6.9%) | 1 (4.5%) | |
| interstitial nephritis | 1 (1.7%) | 1 (4.5%) | |
| Comorbidities Before Transplantation | |||
| arterial hypertension | 56 (96.6%) | 21 (95.5%) | 1 b |
| diabetes mellitus | 8 (13.8%) | 1 (4.5%) | 0.432 b |
Data presented as mean ± standard deviation or absolute and relative frequencies. Abbreviations: BMI, body mass index; ABO-i, ABO incompatible transplantation; ESP, European Senior Program; DGF, delayed graft function; HLA MM, human leucocyte antigen mismatch; PRA, panel reactive antibodies; CMV, cytomegalovirus; ESRD, end-stage renal disease. Two-sided p-value from a Welch′s t-test or b Fisher′s exact test.