Table 3.
Immunosuppression.
| Fast Metabolizers n = 58 |
Slow Metabolizers n = 22 | p-Value | |
|---|---|---|---|
| Prednisolone Dose after 1 Month | 17.5 (5–25) | 15 (5–50) | 0.680 a |
| Mycophenolate after 1 Month | |||
| mycophenolate mofetil, n (%) | 30 (51.7%) | 13 (59.1%) | 0.621 b |
| mycophenolate sodium, n (%) | 28 (48.3%) | 9 (40.9%) | |
| mycophenolate mofetil dose (mg) | 1000 (500–2000) | 1000 (500–2000) | 0.932 a |
| mycophenolate sodium dose (mg) | 1440 (720–1440) | 1080 (720–1440) | 0.213 a |
| Tac Doses (mg) | |||
| IR-Tac M1 | 12 (5–20) | 7 (4–12) | <0.001 a |
| before switch (IR-Tac) | 10.25 (3–18) | 6.75 (1.5–17) | <0.001 a |
| D10 LCPT | 7 (1.5–14) | 3.5 (1.8 11) | <0.001 a |
| M1 LCPT | 6 (1.5–13.5) | 3 (1.5–11) | <0.001 a |
| M3 LCPT | 4.75 (1.5–12) | 3 (1–8) | 0.002 a |
| M6 LCPT | 4 (1.5–12) | 2.5 (0.75–5) | 0.001 a |
| M9 LCPT | 4 (1.5–11) | 2.5 (1–6) | 0.001 a |
| M12 LCPT | 3.63 (1.5–11) | 2.25 (1–5) | 0.001 a |
| M24 LCPT | 3.38 (1–9) | 2.13 (0.75–5.5) | 0.008 a |
| M36 LCPT | 3 (1–8.5) | 2 (0.75–3.5) | 0.016 a |
| Tac trough Levels (ng/mL) | |||
| IR-Tac M1 | 6.8 (2.4–15.9) | 8.7 (6.8–13.5) | <0.001 a |
| before switch (IR-Tac) | 6.3 (2.4–12.3) | 7.5 (3.9–13.5) | 0.065 a |
| D10 LCPT | 7.2 (1.6–14.7) | 6.3 (4.1–9.9) | 0.026 a |
| M1 LCPT | 7.6 (1.5–19.5) | 6.2 (3.7–12.9) | 0.041 a |
| M3 LCPT | 7.3 (3.8–18.1) | 6.7 (4.9–9.9) | 0.311 a |
| M6 LCPT | 7.0 (2.7–11.4) | 6.2 (4.0–10.4) | 0.043 a |
| M9 LCPT | 6.5 (3.4–10.7) | 6.3 (4.2–9.2) | 0.992 a |
| M12 LCPTT | 6.2 (3.5–10.3) | 6.05 (3.8–8.3) | 0.224 a |
| M24 LCPT | 6.2 (4.0–10.7) | 6.2 (2.1–9.4) | 0.254 a |
| M36 LCPT | 5.5 (4.1–8.9) | 5.40 (4.0–8.7) | 0.698 a |
| Tac C/D Ratio (ng/mL·1/mg) | |||
| IR-Tac M1 | 0.64 (0.24–1.01) | 1.25 (1.08–3.38) | <0.001 a |
| before switch (IR-Tac) | 0.66 (0.24–2.10) | 1.15 (0.32–3.60) | 0.001 a |
| D10 LCPT | 1.08 (0.33–4.90) | 1.91 (0.40–4.06) | 0.002 a |
| M1 LCPT | 1.24 (0.21–6.93) | 2.23 (0.55–3.47) | 0.010 a |
| M3 LCPT | 1.52 (0.55–4.93) | 2.33 (0.94–6.60) | 0.004 a |
| M6 LCPT | 1.58 (0.39–5.93) | 2.65 (1.06–7.07) | 0.007 a |
| M9 LCPT | 1.63 (0.40–5.07) | 3.23 (1.23–6.30) | <0.001 a |
| M12 LCPTT | 1.74 (0.42–5.43) | 2.75 (1.08–5.90) | 0.007 a |
| M24 LCPT | 1.81 (0.64–5.40) | 2.58 (0.96–6.27) | 0.083 a |
| M36 LCPT | 1.85 (0.69–5.80) | 2.65 (1.32–5.73) | 0.026 a |
Data presented as median (25% quantile-75% quantile) or absolute and relative frequencies. Abbreviations: Tac, tacrolimus; C/D, concentration-to-dose; two-sided p-values from a Mann–Whitney U test or b Fisher´s exact test.