Table 2.
Associations between cognition and the Zung depression score during the FINGER trial.
| Path | Path Coefficient (Standard Error) | p-Value |
|---|---|---|
| Global cognition | ||
| Baseline Zung and baseline cognition (b0) | ||
| Intervention 1 | −0.372 (0.099) | <0.001 |
| Control 1 | −0.244 (0.100) | 0.015 |
| Best model; combined 2 | −0.302 (0.070) | <0.001 |
| Baseline Zung and cognitive change (b1) | ||
| Intervention 1 | −0.142 (0.085) | 0.095 |
| Control 1 | −0.103 (0.087) | 0.235 |
| Best model; combined 2 | −0.140 (0.050) | 0.005 |
| Zung change and cognitive change (b3) | ||
| Intervention 1 | −0.124 (0.776) | 0.873 |
| Control 1 | −0.404 (0.773) | 0.601 |
| Best model; combined 2 | constrained to 0 | N/A |
| Executive functioning domain | ||
| Baseline Zung and baseline cognition (b0) | ||
| Intervention 1 | −0.393 (0.120) | 0.001 |
| Control 1 | −0.270 (0.122) | 0.027 |
| Best model; combined 3 | −0.360 (0.081) | <0.001 |
| Baseline Zung and cognitive change (b1) | ||
| Intervention 1 | −0.096 (0.113) | 0.396 |
| Control 1 | −0.038 (0.109) | 0.726 |
| Best model; combined 3 | constrained to 0 | N/A |
| Zung change and cognitive change (b3) | ||
| Intervention 1 | 0.593 (0.926) | 0.522 |
| Control 1 | −1.085 (0.915) | 0.235 |
| Best model/intervention 3 | constrained to 0 | N/A |
| Best model/control 3 | −1.371 (0.736) | 0.063 |
| Memory domain | ||
| Baseline Zung and baseline cognition (b0) | ||
| Intervention 1 | −0.218 (0.127) | 0.087 |
| Control 1 | −0.160 (0.120) | 0.185 |
| Best model; combined 4 | −0.177 (0.088) | 0.043 |
| Baseline Zung and cognitive change (b1) | ||
| Intervention 1 | −0.238 (0.130) | 0.068 |
| Control 1 | −0.166 (0.132) | 0.210 |
| Best model; combined 4 | −0.231 (0.083) | 0.005 |
| Zung change and cognitive change (b3) | ||
| Intervention 1 | −0.697 (1.108) | 0.529 |
| Control 1 | −0.296 (1.080) | 0.784 |
| Best model; combined 4 | constrained to 0 | N/A |
| Processing speed domain | ||
| Baseline Zung and baseline cognition (b0) | ||
| Intervention 1 | −0.648 (0.145) | <0.001 |
| Control 1 | −0.344 (0.147) | 0.019 |
| Best model; combined 4 | −0.540 (0.100) | <0.001 |
| Baseline Zung and cognitive change (b1) | ||
| Intervention 1 | −0.069 (0.112) | 0.535 |
| Control 1 | −0.120 (0.108) | 0.268 |
| Best model; combined 4 | constrained to 0 | N/A |
| Zung change and cognitive change (b3) | ||
| Intervention 1 | −1.051 (0.984) | 0.286 |
| Control 1 | 0.604 (0.851) | 0.478 |
| Best model; combined 4 | constrained to 0 | N/A |
Note: Path refers to Figure S1 and Table S2 in Supplementary material. Baseline refers to the latent intercept and change refers to the latent slope estimated with parallel growth curves. All models are adjusted for age, sex, education, trial site, antidepressant use, and healthy lifestyle change index. p-values < 0.05 are shown in bold. 1 Model 2 (see Supplementary Methods in Supplementary material for details), where measurement error covariances are estimated as equal between groups. 2 Model 6 (see Supplementary Methods in Supplementary material for details), where all parameters are estimated as equal and the path slope (Zung)-slope (cognition) is constrained to [0]. 3 Model 6 (see Supplementary Methods in Supplementary material for details), where the path slope (Zung)-slope (cognition) is constrained to [0] in the intervention group. 4 Model 7 (see Supplementary Methods in Supplementary material for details), where all parameters are estimated as equal and the path intercept (Zung)-slope (cognition) is constrained to [0].