TABLE 4.
Therapeutic effect of T-3811ME and reference drugs on experimental pneumonia (PRSP D-979) in mice
| Drug route | Inoculum (CFU/mouse) | Drug | MIC (μg/ml) | ED50 (mg/mouse) | 95% Confidence limit |
|---|---|---|---|---|---|
| Oral | 5.5 × 104 | T-3811ME | 0.032 | 0.0278a | 0.0180–0.0479a |
| Ciprofloxacin | 1 | 0.525 | 0.331–1.618 | ||
| Levofloxacin | 1 | 0.537 | 0.365–1.113 | ||
| Trovafloxacin | 0.063 | 0.0372 | 0.0261–0.0600 | ||
| Subcutaneous | 6.9 × 103 | T-3811ME | 0.032 | 0.0266a | 0.0195–0.0398a |
| Ciprofloxacin | 1 | 0.422 | 0.282–0.898 | ||
| Levofloxacin | 1 | 0.264 | 0.181–0.400 |
a
Equivalent to that of T-3811.