Table 5.
Associations between clinical and biological variables at ICU admission and worsening toward critical condition during the ICU stay.
| Variable | Univariable Analysis | Logistic Regression Full Model a | Logistic Regression Final Model b | |||
|---|---|---|---|---|---|---|
| OR [95%CI] | p | OR [95%CI] | p | OR [95%CI] | p | |
| Age (per 5 years) | 1.56 [1.21–2.09] | 0.001 | 1.23 [0.90–1.75] | 0.2 | ||
| BMI (per kg·m−2) | 0.97 [0.90–1.03] | 0.3 | ||||
| SAPS-II score | 1.09 [1.04–1.14] | 0.0003 | 1.09 [1.04–1.17] | 0.002 | 1.11 [1.06–1.17] | <0.0001 |
| Corticosteroid | 0.20 [0.01–1.61] | 0.2 | ||||
| Anticoagulation | 0.44 [0.08–2.15] | 0.3 | ||||
| A-IPC (per 5 G/L) | 0.72 [0.51–0.96] | 0.04 | 0.46 [0.24–0.77] | 0.009 | 0.47 [0.25–0.76] | 0.007 |
| NLR (per 10%) | 1.60 [1.08–2.49] | 0.03 | 0.97 [0.52–1.80] | 0.9 | ||
| NPR (per unit) | 0.35 [0.01–60.18] | 0.7 | ||||
| Fibrinogen (per g/L) | 1.34 [0.98–1.89] | 0.08 | 1.45 [0.91–2.47] | 0.1 | ||
| vWF activity (per 50 UI/dL) | 1.29 [1.03–1.66] | 0.04 | 1.08 [0.80–1.48] | 0.6 | ||
| Prothrombin F1 + 2 (per 50 pM) | 1.12 [1.02–1.24] | 0.02 | 1.07 [0.94–1.22] | 0.3 | ||
| D-Dimer (µg/L) | 1.00 [0.99–1.00] | 0.3 | ||||
Bold variables are included in the full model for logistic regression a and, if significant, in the final model b A-IPC: absolute immature platelet count; BMI: body mass index; NLR: neutrophils to lymphocytes ratio; NPR: neutrophils to platelets ratio; SAPS-II: Simplified Acute Physiology Score II; vWF: von Willebrand factor.