Table 6.

Searching for hypertension-related molecular markers among the human genes orthologous to the 42 hippocampal DEGs (of tame versus aggressive rats) identified in this work. Here, we took into account the number of their homologous DEGs in the tissues of hypertensive versus normotensive subjects (patients and animals).

Rat Gene		Total Number of DEGs		Binomial Distribution		Rat Gene		Total Number of DEGs		Binomial Distribution
#	Symbol	NPC1: Opposite Signs	NPC2: Matching Signs	p	P ADJ	#	Symbol	NPC1: Opposite Signs	NPC2: Matching Signs	p	P ADJ
i	ii	iii	iv	v	vi	i	ii	iii	iv	v	vi
1	Alb	1	1	0.75	1.00	22	Pcdhga1	1	1	0.75	1.00
2	Aqp1	6	6	0.61	1.00	23	Pdyn	0	0	ND	ND
3	Ascl3	1	1	0.75	1.00	24	Pla2g2d	19	12	0.14	1.00
4	Bag3	2	2	0.69	1.00	25	Pla2g5	19	12	0.14	1.00
5	Baiap2l1	1	0	0.50	1.00	26	Plod1	3	1	0.31	1.00
6	Bdh1	2	0	0.25	1.00	27	Ppp1r3b	2	3	0.50	1.00
7	Cckbr	1	0	0.50	1.00	28	Prlr	0	1	0.50	1.00
8	Cspg4b	0	0	ND	ND	29	Pygl	0	1	0.50	1.00
9	Defb17	2	3	0.50	1.00	30	Rbm3	15	12	0.35	1.00
10	Enpp2	3	8	0.11	1.00	31	Retsat	5	2	0.23	1.00
11	Frem1	1	1	0.75	1.00	32	Slc16a12	7	6	0.50	1.00
12	Gpd1	4	1	0.19	1.00	33	Slc4a5	7	5	0.83	1.00
13	Hbb-b1	24	3	10−4	10−3	34	Smoc2	3	1	0.31	1.00
14	Hnf4a	0	0	ND	ND	35	Spint1	1	1	0.75	1.00
15	Htr2c	3	3	0.65	1.00	36	Sulf1	0	0	ND	ND
16	Krt2	22	13	0.09	1.00	37	Sync	0	0	ND	ND
17	Lilrb3l	10	1	10−2	0.24	38	Tc2n	2	0	0.25	1.00
18	Lypd1	11	7	0.24	1.00	39	Tecta	0	1	0.50	1.00
19	Morn1	0	4	0.06	1.00	40	Tmem60	0	0	ND	ND
20	Myom2	2	1	0.50	1.00	41	Txnrd2	2	0	0.25	1.00
21	Pcdhb9	10	0	10−3	0.05	42	Ucp2	1	1	0.75	1.00

Note. p and P_ADJ: a significance estimate according to the binomial distribution without or with Bonferroni’s correction for multiple comparisons, respectively; ND: not detected; underlining: statistically significant hypertension-related molecular markers identified in this work.