Table 9.

Comparing the effects of changes to the expression of homologous genes (a) on hypertension development in humans and (b) during the divergence of domestic and wild animals from their most recent common ancestors.

(a) Humans					(b) Animals
Gene	Effect of Gene Expression Changes on Hypertension (HT): Hypertensive (→) or Normotensive (←)				RNA-Seq		Effect of Gene Expression Changes during Divergence from the Most Recent Common Ancestor			Ref.
	Downregulation	HT	Upregulation	HT	DEG	log2	Downregulation	Upregulation	Tissue
i	ii	iii	iv	v	vi	vii	viii	ix	x	xi
HBB, HBD	low blood viscosity [199]	←	high-altitude environment provokes hyperhemoglobinemia and hypertension [103]	→	Hbb-b1	−6.19	tame rat	aggressive rat	hippocampus	[this work]
					Hbb-b1	−3.97	tame rat	aggressive rat	hypothalamus	[72]
					Hbbl	−5.92	dogs	wolves	blood	[189]
					Hba1	−4.06	dogs	wolves	blood	[189]
					Hbad	−1.07	domestic chickens	wild chickens	pituitary	[193]
					Hbm	−6.46	dogs	wolves	blood	[189]
					Hbz1	−7.10	dogs	wolves	blood	[189]
PCDHB9	wide vascular inner diameter [200]	←	higher risks of gastric cancer [93], surgical removal of which relieves hypertension [12]	→	Pcdhb9	−1.03	tame rat	aggressive rat	hippocampus	[this work]
					Pcdhb9	−1.01	tame rat	aggressive rat	hypothalamus	[72]
					Pcdhb15	−1.04	domestic rabbits	wild rabbits	parietal-temporal cortex	[188]