Table 1.
Survival and hospital course parameters.
| Characteristic (n = 76) | Value |
|---|---|
| Demographics, severity of illness and outcome data | |
| Age in years (mean ± SD) | 64.4 ± 12.5 |
| BMI kg/m2 (mean ± SD) | 27.5 ± 3.9 |
| ICU LOS days (mean ± SD) | 21.8 ± 15.4 |
| APACHE II on admission (mean ± SD) | 26.1 ± 8.3 |
| Vasoactive-inotropic score max. (mean ± SD) | 85.0 ± 36.8 |
| Outcome of death in ICU (%) | 35 (46.1) |
| Core body temperature and temperature management data | |
| Temperature on admission (mean ± SD) | 38.0 ± 1.0 |
| Fever (>38.3 °C) prevalence N (%) | 62 (82) |
| Temperature before TTM (mean ± SD) | 40.0 ± 0.4 |
| ECD N (%) | 22 (28.9) |
| TTM duration in days (mean ± SD) | 5.0 ± 1.9 |
| Max. core body temperature during TTM (°C) (mean ± SD) | 39.2 ± 0.38 |
| % of ToTT (mean ± SD) | 27.5 ± 10.1 |
| % of time above 39 °C during TTM | 16.9 ± 7.4 |
| RRT N (%) | 28 (36.8) |
| Procedures–pharmacological therapy | |
| Acetaminophen g/day (mean ± SD) | 2.1 ± 0.93 |
| Noradrenaline max dose mcg/kg/h (mean ± SD) | 0.83 ± 0.23 |
| Procedures–mechanical ventilation | |
| PEEP max during TTM cmH2O (mean ± SD) | 11.5 ± 1.5 |
| FiO2 max during TTM % (mean ± SD) | 51.2 ± 10.8 |
| MV max during TTM L/min (mean ± SD) | 11.6 ± 2.4 |
| Complications, multidrug resistant pathogens | |
| Sacral pressure sores N (%) | 25 (32.9) |
| Upper GIT bleeding N (%) | 6 (7.9) |
| Erythrocyte transfusion number of bags (mean ± SD) | 2.8 ± 2,7 |
| MDRP present N (%) | 49 (75.4) |
Legend: BMI: body mass index; ICU: intensive care unit; LOS: length of stay; APACHE II: acute physiology and chronic health evaluation score II; ECD: esophageal cooling device; TTM: targeted temperature management; ToTT: time outside target temperature; RRT: renal replacement therapy; PEEP: positive end-expiratory pressure; FiO2: fraction of inspired oxygen; MV: minute ventilation; MDRP: multidrug resistant pathogens.