Figure 1.

Pathologic evaluation of myocardial and intestinal tissue in a 72-year-old woman (Case 1) affected by Fabry disease before and after 2 years of agalsidase-α. (A–F) Myocardium unchanged cardiomyocyte dimensions and vacuolar area in H&E (A,B), immunofluorescence for Gb3 (C,D) and electron microscopy (E,F) comparing pre (A,C,E) and post (B,D,F) findings. (G–J) Intestinal tissue mobilization of Gb3 in immunofluorescence (G,H) and ultrastructural examination (I,J), comparing pre- (G,I) and post-treatment (H–J) features.