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. 2022 Feb 24;27(5):1536. doi: 10.3390/molecules27051536
CMAs critical material attributes
CPPs critical process parameters
CQAs critical quality attributes
DLS dynamic light scattering
DPPC 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
DSPC 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine
DSPE–PEG3000 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000]
DSC differential scanning calorimetry
EMA European medicine agency
FT-IR Fourier-transform infrared spectroscopy
ΔHm enthalpy change
ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use
MAs material attributes
TSL thermosensitive liposomes
LTSL low-temperature sensitive liposomes
HTSL high-temperature sensitive liposomes
PBS phosphate-buffered saline
PSS 0.9% NaCl solution (physiological saline solution)
PdI polydispersity index
QbD quality by design
QTPP quality target product profile
R&D research and development
RA risk assessment
TEM transmission electron microscopy
TGA thermogravimetric analysis
Tg glass transition temperature
Tm phase transition temperature