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Comparison of kinetic parameters for benzylpenicillin, amoxicillin, and ticarcillin for PSE-1 and TEM-1
| β-Lactamase | Benzylpenicillin
|
Amoxicillin
|
Ticarcillin
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Km (μM) | Relative Vmaxa | Relative Vmax/Kma | Km (μM) | Relative Vmax | Relative Vmax/Km | Km (μM) | Relative Vmax | Relative Vmax/Km | |
| PSE-1 | 30 | 100 | 100 | 68.4 | 49.6 | 22 | 47.4 | 54 | 34.5 |
| TEM-1 | 40 | 100 | 100 | 43.5 | 70 | 65 | 15 | 9.2 | 24.5 |
Relative Vmax and relative Vmax/Km ratio are expressed relative to the values for benzylpenicillin.
