Table 1.

2⁵⁻¹ fractional factorial design was used for the preliminary study with the experimental domain of the independent factors and observed values of target responses.

Run	Factors										Responses
	A: Temperature [°C]		B: Extraction Time [min]		C: L/S Ratio [g NADES/g DW]		D: NADES Type *		E: Water Content [%]		TP [mg GAE/g]	DPPH [mg TE/g]
1	−1	50	1	120	1	20	Level 2	N16	−1	20	57.79	74.55
2	1	60	−1	60	1	20	Level 2	N16	−1	20	63.41	84.86
3	−1	50	1	120	−1	10	Level 2	N16	1	25	53.57	63.45
4	−1	50	1	120	1	20	Level 1	N15	1	25	54.19	57.96
5	−1	50	−1	60	1	20	Level 1	N15	−1	20	50.62	54.25
6	1	60	−1	60	1	20	Level 1	N15	1	25	52.11	52.50
7	1	60	1	120	−1	10	Level 1	N15	1	25	44.13	37.59
8	1	60	1	120	−1	10	Level 2	N16	−1	20	59.52	69.75
9	−1	50	−1	60	−1	10	Level 2	N16	−1	20	51.87	54.60
10	1	60	1	120	1	20	Level 1	N15	−1	20	52.37	54.25
11	−1	50	−1	60	1	20	Level 2	N16	1	25	58.47	64.19
12	1	60	1	120	1	20	Level 2	N16	1	25	64.24	91.16
13	−1	50	−1	60	−1	10	Level 1	N15	1	25	43.31	39.97
14	1	60	−1	60	−1	10	Level 2	N16	1	25	54.84	72.47
15	−1	50	1	120	−1	10	Level 1	N15	−1	20	44.45	40.13
16	1	60	−1	60	−1	10	Level 1	N15	−1	20	44.93	39.88

* categorical variable.