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. 2022 Mar 7;27(5):1747. doi: 10.3390/molecules27051747

Figure 3.

Figure 3

Structural position in the menin model of wild-type buried residues affected by mutations predicted as destabilizing. Affected residues are shown as red stick models: L22R, L39W, A49V, I86F, L89R, L157W, A165T, V167F, L180R, A181S, W188S, W188C, V189E, V201G, L261F, L264R, L278P, P282H, A289Q, A289E, A289V, A342D, I353N, Y358D, A373D, I377M, F415L, L418R, L419Q, I425N, W428R, and I580N. The enlarged view shows the investigated residues in the two α/β motifs colored in pale cyan and teal, respectively.