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. 2022 Mar 7;27(5):1747. doi: 10.3390/molecules27051747

Figure 6.

Figure 6

Detail of menin-MLL1 and menin-JunD interactions related to residue E371 and its mutation. (A) interactions between menin wild type E371 and MLL1 R24; (B) interaction between menin E371D variant and MLL1. (C) interactions between menin wild type and JunD; (D) interactions between menin mutated in E371D and JunD. Menin is represented in green cartons with residues E/D371 involved in the interactions highlighted in green balls and sticks. MLL1 and JunD are represented in orange and cyan cartons, respectively, with residues involved in the interactions highlighted in orange/cyan balls and sticks. Green dashed lines correspond to the H-bond, violet dashed lines to salt-bridges, orange dashed lines to electrostatic interaction, white dashed line to Carbon H-bond.