Figure 2.

In vivo systemic toxicity associated with three biomaterials. (a1–a3) H&E staining of the hearts in the control, 30-day and 150-day groups. (b1–b3) H&E staining of the livers in the control, 30-day and 150-day groups. (c1–c3) H&E staining of the spleens in the control, 30-day and 150-day groups. (d1–d3) H&E staining of the lungs in the control, 30-day and 150-day groups. (e1–e3) H&E staining of the kidneys in the control, 30-day and 150-day groups. No significant inflammatory infiltration or tissue necrosis was observed. p ˃ 0.05 versus the normal group. (100×, bar, 300 μm; insets show tissue details at 400×, bar, 60 μm).