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. 2022 Mar 7;15(5):1962. doi: 10.3390/ma15051962

Figure 4.

Figure 4

In vivo macrophage polarization in response to three biomaterials. (a) Localizations of CD86-positive and CD163-positive cells in rat subcutaneous connective tissues at 7, 30 and 150 days after implantation of empty dentine tubes (control), MTA, SP and HiFlow. The nuclei were stained with DAPI (400×, bar, 200 μm). (b) Fluorescence semiquantitative statistical analysis of M1 and M2 macrophages at 7, 30 and 150 days. * p ˂ 0.05, ** p ˂ 0.01, *** p ˂ 0.001, **** p ˂ 0.0001 versus the control group.