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. 2022 Mar 1;27(5):1636. doi: 10.3390/molecules27051636

Table 6.

Toxicity properties of Jusanin and reference.

Comp. FDA Rodent Carcinogenicity
(Mouse-Male)
Carcinogenic Potency TD50
(Rat) a
Rat Maximum Tolerated Dose
(Feed) b
Rat Oral LD50 b Rat Chronic LOAEL b Ocular Irritancy Skin Irritancy
Jusanin Non-Carcinogen 13.5782 0.3502 0.4621 0.0624 Mild Non-Irritant
Simeprevir Non-Carcinogen 0.2803 0.0030 0.2088 0.0021 Mild Non-Irritant

a Unit: mg/kg body weight/day b Unit: g/kg body weight.