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. 2022 Mar 10;17(3):e0265130. doi: 10.1371/journal.pone.0265130

Table 3. Factors associated with antibody response by univariate, multivariate and propensity score analysis.

Univariate Analysis Multivariate logistic regression Propensity score Analysis
Variables  OR  95% CI P  Variables  OR  95% CI P  Variables  aOR  95% CI  P
Age (Per 10-year increase)  0.66  0.60–0.82  <0.001  Age (Per year increase)  0.61  0.48–0.78  <0.001  Steroids  0.64  0.28–1.50  0.31
Female gender  1.34  0.88–2.04  0.17  BMI  1.06  1.00–1.13  0.06  MPA  0.17  0.07–0.41  <0.001
Ethnicity  1.16  0.87–1.54  0.32  MPA  0.02  0.01–0.11  <0.001  Triple IS  0.96  0.34–2.73  0.94
BMI (Per 1mg/kg2)  1.03  0.99–1.06  0.18  Steroid  0.27  0.04–1.97  0.20  Vaccine (AZD1222 vs BNT162b2)  0.93  0.41–2.13  0.87
Diabetes  0.82  0.53–1.27  0.39  CNI  0.20  0.02–2.39  0.21         
CVD  0.58  0.36–0.93  0.03 Time since transplantation/y 1.05  0.98–1.12  0.19        
Primary renal disease  1.07  0.96–1.18  0.22  BK Viremia  2.58  0.83–8.02 0.10         
Time since transplantation/y  1.09  1.06–1.14  <0.001 eGFR α, β  1.40  1.19–1.66  <0.001         
Cancer  0.75  0.33–1.70  0.49  Vaccine (AZD1222 vs BNT162b2)  0.58  0.30–1.13  0.11         
CNI  0.35  0.13–0.95  0.04 Number of IS 1.64 0.25–10.73 0.60
MPA  0.10  0.06–0.20  <0.001
Steroid  1.53  0.99–2.36  0.06 
Number of IS  0.58  0.39–0.86  0.007 
eGFR α, β  1.12  1.01–1.25  0.03 
eGFR ≥ 30 α  1.10  0.64–1.91  0.73 
eGFR ≥ 60 α  1.90  1.16–3.09  0.01
Donor type  0.99  0.64–1.51  0.95 
BK virus  2.50  1.17–5.33  0.02
CMV  0.68  0.35–1.31  0.25 
EBV  0.67  0.30–1.50  0.33 
Acute rejection  2.37  1.28–4.38  0.006 
Vaccine (AZD1222 vs BNT162b2)  0.76  0.46–1.27  0.29 

α, the Modification of Diet in Renal Disease eGFR;

β, per 10 ml/min/1.73m2 increase; AZD1222, Oxford/AstraZeneca vaccine; aOR, adjusted odds ratio; BMI, body mass index; BNT162b2, Pfizer-BioNTech vaccine; CI, confidence interval; CMV, cytomegalovirus; CNI, calcineurin inhibitor; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; EBV, Epstein bar virus; IS, immunosuppression; MPA, mycophenolic acid; MDRD, modification of diet in renal disease, OR, odds ratio; y, year