Table 1.
The various properties of modified PCL membranes.
| Year [Ref.] | Main Membrane Material |
Modifications | Additional Properties | Drawbacks |
|---|---|---|---|---|
| 2019 [32] | MNA, PCL, polydopamine |
Coated with polydopamine and the addition of MNA |
Controlled MNA release for antibacterial activity |
Not mentioned |
| 2021 [33] | Polylactic acid (PLA)/cellulose acetate (CA) or PCL, AgNPs, hydroxyapatite nanoparticles (HANPs) | Adding AgNPs, HANPs | Sustained antibacterial activity, optimized mechanical properties, lowered degradation rate, enhanced cell proliferation |
HANPs: 20 wt%, decreased tensile property |
| 2018 [34] | PCL, PEG, bioactive glass (BGs) | Adding BGs | Suitable mechanical and biodegradable properties, hydrophilic surface, higher proliferation rates of adipose-derived stem cells, good bone mineralization capacity |
Not mentioned |
| 2018 [36] | F18 bioactive glass, PCL | Adding F18 bioactive glass |
Enhanced osteogenesis and excellent tensile strength |
Not mentioned |
| 2017 [37] | Si-NPs, PCL | Adding Si-NPs | Improved mechanical properties | Not mentioned |
| 2019 [39] | SiO2-CaO-P2O5 and SiO2-SrO-P2O5, bisphosphonate drug ibandronate, PCL | Two different types of mesoporous bioactive glasses, bisphosphonate drug ibandronate |
Bioactive glass enhanced hydrophilicity and bioactivity; Sr+ bisphosphonate drug ibandronate improved osteogenesis |
Not mentioned |
| 2015 [40] | PCL, ZnO | Adding ZnO | Antibacterial properties, enhanced cell proliferation/wound healing |
Decreased mechanical suitability after adding ZnO; adding 30 wt% ZnO decreased viability |
| 2018 [41] | metronidazole (MNA), nano-hydroxyapatite (NHA), PCL, gelatin | Adding MNA, NHA, forming core-shell structure | Promoted osteogenesis and slow MNA release for antibacterial activity | Not mentioned |
| 2018 [42] | PCL, NHA/BG | Adding NHA/BG | Enhanced mechanical properties, excellent cell attachment | The membrane with a high nHA/BG loading density was pooer than the low one |
| 2020 [43] | EBPs, PCL, hydroxyapatite (HA) |
Forming nanopattern and the addition of EBPs |
EBPs enhanced surface hydrophilicity; nanopattern and EBPs enhanced the osteogenic phenotype of human dental pulp stem cells (DPSCs) |
Not mentioned |
| 2019 [44] | PCL, Strontium-substituted hydroxyapatite nanofibers (SrHANFs) |
Adding SrHANFs | Promoted differentiation and mineralization of osteoblast-like cells |
Not mentioned |
| 2019 [45] | PCL PolyHIPE | Air plasma treatment |
PCL PolyHIPE layer promoted osteogenesis, Ca and mineral deposition of bone cells, the deposition of collagen; electrospun nanofibrous PCL layer promoted cell-occlusion |
Not mentioned |
| 2018 [46] | BG, PCL | Adding BG | Excellent mechanical properties | Not mentioned |
| 2016 [47] | PCL, bioactive CaO-SiO2, |
Hydroxyapatite-coated | Osteoconductivity and excellent bone formation ability |
Not mentioned |
| 2018 [48] | PCL, gelatin, chitosan, β-tricalcium phosphate (β-TCP) |
Adding β-TCP | Enhanced osteogenesis, adjustable degradation rate, more wettable surface, suitable mechanical properties |
Not mentioned |