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. 2022 Mar 4;14(5):1087. doi: 10.3390/nu14051087

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of NHDC and GNHDC on lipogenesis, adipogenesis, and proinflammatory cytokines in 3T3-L1 cells. Expression of mRNA was analyzed for (A) lipogenesis-related genes, (a) Srebp1c and (b) Fas, (B) adipogenesis-related genes, (a) Pparγ and (b) C/ebpα, (C) proinflammatory cytokines-related genes, (a) Tnfα, (b) Il-1β, and (c) Mcp1. All data are shown as the mean ± SEM and were analyzed by an unpaired Student’s t-test (n = 3–4). Each asterisk indicates significant difference as compared to Ctrl; * (p < 0.05) and ** (p < 0.01). C/ebpα, CCAAT/enhancer binding protein alpha; Fas, fatty acid synthase; Il-1β, interleukin 1 beta; Mcp1, monocyte chemoattractant protein 1; Pparγ, peroxisome proliferator-activated receptor gamma coactivator 1 alpha; Srebp1c, sterol regulatory element-binding protein 1; Tnfα, tumor necrosis factor alpha; Ctrl, control; NHDC, neohesperidin dihydrochalcone; GNHDC, NHDC-O-glycoside.