TABLE 2.

Binding of MK-0826 and other agents to PBPs of E. coli KN126

PBP	IC50 (μg/ml) of:
	MK-0826a	Imipenemb	Ceftriaxonec	Cefepimed
1a	0.1	0.02	0.03	3.8
1b	0.2	0.3	0.4	1.9
2	0.01	0.01	0.4	0.3
3	0.04	2.9	0.03	0.03
4	0.1	0.2	40	73
5	0.1	0.1	>75	>75
6	5.3	0.2	23	74

^aAt the doses of 7.5 × 10⁴ and 7.5 × 10⁵ CFU/ml, the MICs were both 0.016 μg/ml. 

^bAt the doses of 7.5 × 10⁴ and 7.5 × 10⁵ CFU/ml, the MICs were both 0.5 μg/ml. 

^cAt the doses of 7.5 × 10⁴ and 7.5 × 10⁵ CFU/ml, the MICs were 0.03 and 0.06 μg/ml, respectively. 

^dAt the doses of 7.5 × 10⁴ and 7.5 × 10⁵ CFU/ml, the MICs were 0.03 and 0.06 μg/ml, respectively.