Table 2.
Anti-cancer studies using polysaccharide–drug formulation.
| Formulation | Model Used | Biological Changes | Reference |
|---|---|---|---|
| PTX-trimethyl chitosan conjugates | H22 tumor-bearing mice | Enhanced mucoadhesion and intestinal transport of PTX, increased tumor retardation and survival rate |
[59] |
| Erlotinib-loaded MTX-chitosan magnetic nanoparticles | OVCAR-3 cell lines, | Improved cellular uptake, greater cytotoxicity and target specific delivery in FR-positive cancer cell lines |
[64] |
| Curcumin-loaded chitosan nanoparticles | Swiss albino mice | Inhibiting the B[a]P-induced lung carcinogenesis, overexpression of p65 in the nuclei, reduced the overexpression of proliferating cell nuclear antigen |
[67] |
| Curcumin-loaded folate-modified-chitosan-nanoparticles | MCF7 cell lines, L929 cell lines |
Target specific uptake of curcumin into cancerous cells | [68] |
| Alginate nanoparticles with curcumin and resveratrol | DU145 prostate cancer cells | Increased cell uptake and enhanced cytotoxicity in cancer cells | [87] |
| EXE-loaded alginate nanoparticles | Dalton’s lymphoma ascites cells | Improved cytotoxicity | [90] |
| Ag/Alg-TMX-PEG/FA core shell nanocomposite | MCF7 cell lines | Inducting reactive oxygen species (ROS), downregulation of survival oncogenic genes, G2/M phase arrest |
[93] |
| Pectin–curcumin composite | KYSE-30 cell lines | Release of curcumin from the composite at acidic pH, enhanced cytotoxicity |
[101] |
| Dihydroartemisinin-loaded DOX–pectin conjugate | MCF-7 cell lines, C57BL/6 mouse |
Intranuclear uptake in MCF-7 cell lines, significant reduction in tumor growth |
[103] |
| MTX-loaded guar gum microspheres | Albino rats | Target specific delivery to the colon | [114] |
| Dextran–DOX micelles | Balb/C mice bearing 4T1 tumors | Acid-sensitive drug release minimize systemic toxicity in normal tissues Selective accumulation in tumor and enhanced tumor-suppressive efficiency |
[122] |
| MTX-loaded dextran–CUR nanoparticles | MCF-7 cell lines | Rapid internalization and enhanced cytotoxicity | [133] |
| PTX–HA conjugate | MCF-7 cell lines BALB/c nude mice |
Cellular internalization, and tumor targeting via CD44 caveolae-mediated endocytosis, target specific drug release in the presence of GSH |
[137] |
| Paclitaxel-loaded cyclodextrin–polypeptide conjugates | MCF-7 and 4T1 cell lines | Enhanced cellular uptake, inhibit P-gp efflux pumps |
[157] |
| Mitoxantrone loaded modified pullulan nanoparticles | MB49 cells | Inhibit the growth migration of MB49 cells | [164] |