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. 2022 Feb 28;12(5):821. doi: 10.3390/nano12050821

Table 1.

Description of nanobiosensors.

Biorecognition Material Salmonella Species Nanomaterial Type Transducer Linear Range Sequence LOD Sample Ref.
DNA Salmonella Choleraesuis AuNPs-1
AuNPs-2		 Colorimetric - 5′-HS-AAAAAAAAAACTTAGCTGACATCATG-3′ (imm1)
5′-CGAGTCAGAGTAGTTTAAAAAAAAAA-SH 3′ (imm2)		 50 nM - [15]
Salmonella Typhimurium AuNPs Colorimetric - 5′-GAACGGCGAAGCGTACTGGAA-3 (RP)
5′-CATCGCACCGTCAAAGGAACC-3′ (FP)		 21.78 ng/mL - [28]
Salmonella spp. AuNPs Colorimetric 10–103 CFU/mL 5′ -ACCCACGCGTTTCATCGGTT-3′
5′ -GCCGGCAATCCCTATCACCC-3′		 <10 CFU/mL [29]
Salmonella Enteritidis AuNPs-SA Colorimetric 102–107 CFU/mL 5′CGGGGAGGAAGGTGTTGTGGTTAATAACCGCAGCAATTGACGTTA CC-3′ 3 × 103 CFU/mL - [30]
Salmonella enterica c-MWCNT/AuNP Eletrochemical 0–31.7 pg/μL 5′-GTCCGGGTCAGCCTGAAT -3′ 0.3 pg/mL milk [4]
Salmonella enterica MNPs-DNA-AuNPs Eletrochemical 7–50 ng/mL 5′-CTAACAGGCGCATACGATCTGACA-3 (FP)
5′-TACGCATAGCGATCTCCTTCGTTG-3′ (RP)		 <100 ng/mL Milk and orange juice [18]
typhoidal Salmonella Fe3O4-NPs/CGO/GCE Eletrochemical 1–1 × 10−8 nmol/L 5′-GGCGGCGGGCGTCGCGCACG-3′ 3.16 aM [31]
Salmonella AuNPs-HRP-SA Eletrochemical 9.6–9.6 × 104 PFU/mL 5′-TCGGCATCAATACTCATC-3′ 8.07 PFU/mL - [3]
Salmonella-specific AuNPs Eletrochemical 10 aM–10 pM 5′-GCATCCGCATCAATAATACCG-3′ (FP)
5′ TTCTCTGGATGGTATGCCC-3′ (RP)		 6.76 aM milk [32]
Salmonella Enteritidis CuNPs Fluorescence 50–104 CFU/mL 5′-TACCAAAATGTTGGATTGGATGTTGTACTGGGTTGCA-3′ 25 CFU/mL [33]
Salmonella Typhimurium AuNPs Reflectivity 1 × 103–1 × 108 ng/mL HS-T10-CAATCCGGACTACGACGCAC (CP)
TTTATGAGGTCCGCTTGCTCTTTTTT-SH (DP)		 0.01−100 ng/mL - [34]
APTAMER Salmonella-specific AuNPs Eletrochemical 2.4–2.4 × 103 CFU/mL 5′-HS-TATGGC GGC GTC ACC CGA CGG GGA CTT GAC ATT ATG ACA-G-3′. 3 CFU/mL pork [14]
Salmonella Typhimurium QD/UCNP-MB Luminescence 50–106 CFU/mL 5′-TATGGCGGCGTCACCCGACGG GGACTTGACATTATGACAG-3′
5′-GGCGGTGTGAGGCTGGGAGGACGGACTGGG-3′ (cDNA)		 28 CFU/mL [35]
Salmonella Typhimurium AuNPs
(Apt-Au-PDMS film)		 SERS 27–2.7 × 105 CFU/mL 5′-SH-AGTAATGCCCGGTAGTTATTCAAAGATGAGTAGGAAAAGA-3′ 27 CFU/mL - [17]
Salmonella Typhimurium AuNPs SERS 101–105 CFU/mL 5′ -TATGGCGGCGTCACCCGACGGGGACTTGACATTATGACA G-3′ 4 CFU/mL. pork [2]
Salmonella MGNPs (Fe3O4) and AuNPs SERS 102–107 CFU/mL 5′-SH-TAT GGC GGC GTC ACC CGA CGG GGA CTT GAC ATT ATG ACA G-3′ 15 CFU/mL pork [36]
Salmonella Typhimurium AuNPs LSPR 104–106 CFU/mL 5′-TATGGCGGCGTCACCCGACGGGGACTTGACATTATGACAG-SH-3′ 104 CFU/mL pork [37]
Salmonella Typhimurium AuNPs Fluorescence 1.5 × 102–9.6 × 104 CFU/mL 5′-CCAAAGGCTACGCGTTAACGTGGTGTTGG−3′(Apt1)
5′-ATAGGAGTCACGACGACCAGAAAGTAATGCCCGGTAGTTATTCAAAGATGA GTAGGAAAAGATATGTGCGTCTACCTCTTGACTAAT-3′(Apt2)		 464 CFU/mL [38]
Salmonella Typhimurium SA-FSiNPs Fluorescence - 5′-biotin-(CH2)6-AGTAATGCCCGGTAGTTATTCAAAGATGAGTAGGAAAAGA-3′
5′-biotin-(CH2)6-TGTCATGACCCGTAGGTAGTCTTAGAAGACTAGGCACGTT-3′		 80 CFU/mL [39]
Salmonella Typhimurium MNPs (Fe3O4)
and CdTe QDs		 Fluorescence 10–1010 CFU/mL 5′-biotin-C6-TATGGCGGCGTCACCCGACGGGGACTTGACATTATGACAG-3′(ssDNA1)
5′-C6-NH2-CTGTCATAATGTCAAGTC-3′(ssDNA2)		 1 CFU/mL [40]
Salmonella Typhimurium AuNPs Colorimetric - 50 -CCAAAGGCTACGCGTTAACGTGGTGTTGG −30 105 CFU/mL - [41]
Salmonella Typhimurium MNPs (Fe3O4) Colorimetric - 5′-GAGGAAAGTCTA- TAGCAGAGGAGATGTGTGAACCGAGTAA-3 7.5 × 105 CFU/mL [12]
Salmonella Typhimurium AuNPs and MNPs (Fe3O4) UV/Vis 25 to 105 CFU/mL 5′-SH-ATAGGAGTCACGACGAC-CAGAAAGTAATGCCCGGTAGTTATTCAAAGATGAGTAG-GAAAAGATATGTGCGTCTACCTCTTGACTAAT-3′ (apt 1)
5′-Bio-ATAGGAGTCACGACGACCAGAAAGTAATGCG-CGGTAGTTATTCAAAGATGAGTAGGAAAAGATATGTGC-GTCTACCTCTTGACTAAT-3′ (apt2)		 10 CFU/mL milk [42]

Legend: (-) not reported; AuNPs (gold nanoparticles); MB: magnetic beads UCNP: upconverting nanoparticle; QD: quantum dot; cDNA: DNA complementary; SGNPs (spiny gold nanoparticles); MGNPs (magnetic gold nanoparticles); MNPs (Fe3O4) (magnetic nanoparticles of Fe3O4); CdTe QDs (cadmium telluride quantum dots); UV/Vis (ultraviolet–visible); QD/UCNP-MB (quantum dots upconverting nanoparticle of magnetic beads); MNPs-DNA-AuNPs (DNA-coupled magnetic nanoparticles and sandwich-shaped gold nanoparticles); Fe3O4-NPs/CGO/GCE (graphene oxide modifying glassy carbon electrode coupled with oxide iron nanoparticles); Apt-Au-PDMS film (aptamer–Au nanoparticles–polydimethylsiloxane film); c-MWCNT/AuNP FP (carboxylated multiwalled carbon nanotube and gold nanoparticle); AuNPs-SA (gold nanoparticles–streptavidin); SA-FSiNPs (streptavidin-conjugated nanoparticle silica fluorescence); AuNPs-HRP-SA (horseradish peroxidase–streptavidin biofunctionalized gold nanoparticles); CuNPs (copper nanoparticles); CFU (colony-forming unit); PFU (plaque-forming unit); FP (forward primer); RP (reverse primer); CP (capture probe); DP (detection probe); Salmonella spp. (S. Agona, S. Anatum, S. Berta, S. Derby, S. Dublin, S. Enteriditis, S. Gallinarum, S. Heidelberg, S. Infantis, S. Javiana, S. Kentucky, S. Mbandaka, S. Montevideo, S. Muenster, S. Newport, S. Oranienburg, S. Saintpaul, S. Senftenberg, S. Thompson, and S. Typhimurium); Apt-MNPs (aptamer-coated Fe3O4 magnetic particles); LSPR (localized surface plasmon resonance); SERS (surface-enhanced Raman scattering).