Table 3.
Linear associations of relative abundances of taxa with HbA1c level in Chinese diabetes patients.
| Phylum | Class | Order | Family | Genus/Species | Relative Abundance (%) |
Transformed Abundance (%) |
β [95%CI] for HbA1c (%) |
p-Value | Q-Value |
|---|---|---|---|---|---|---|---|---|---|
| All subjects at the first follow-up (n = 325) | |||||||||
| Euryarchaeota | 0.000 (0.000, 0.003) | 0.000 (0.000, 0.506) | 0.19 [0.08, 0.31] | 0.001 | 0.013 | ||||
| Euryarchaeota | Methanobacteria | Methanobacteriales | Methanobacteriaceae | Methanobrevibacter | 0.000 (0.000, 0.002) | 0.000 (0.000, 0.438) | 0.24 [0.10, 0.38] | 0.001 | 0.053 |
| Bacteroidetes | Bacteroidia | Bacteroidales | Prevotellaceae | (Unknown) | 0.000 (0.000, 0.001) | 0.000 (0.000, 0.386) | 0.30 [0.09, 0.52] | 0.006 | 0.131 |
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | (Unknown) | 0.743 (0.243, 2.283) | 8.630 (4.928, 15.168) | 0.03 [0.01, 0.06] | 0.006 | 0.131 |
| Firmicutes | Erysipelotrichi | Erysipelotrichales | Erysipelotrichaceae | Holdemania | 0.006 (0.002,0.014) | 0.754 (0.390, 1.184) | 0.33 [0.11, 0.55] | 0.004 | 0.120 |
| Proteobacteria | Alphaproteobacteria | Rhizobiales | Methylobacteriaceae | (Unknown) | 0.000 (0.000, 0.000) | 0.000 (0.000,0.000) | 1.66 [0.88, 2.44] | 0.000 | 0.006 |
| Proteobacteria | Deltaproteobacteria | Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio | 0.036 (0.022, 0.191) | 1.909 (1.472, 4.367) | 0.05 [0.02, 0.09] | 0.001 | 0.053 |
| All subjects at the second follow-up (n = 301) | |||||||||
| -- | |||||||||
All taxa listed with Q-values less than 0.15; abundance of taxa presented as median (IQR); β coefficients [95%CI] for HbA1c with per unit of transformed abundance of taxa, and adjusted for age, sex, education level, duration of diabetes, intervention status in parent trial, physical activity level, energy intake, fat intake, use of anti-diabetes agents and NSAIDs within six months before stool collection.