Table 4.
Associations of habitual dietary fiber intake with relative abundances of taxa in Chinese diabetes patients.
| Phylum | Class | Order | Family | Genus | Relative Abundance (%) |
Transformed Abundance (%) |
β [95%CI] with Dietary Fiber Intake |
p-Value | Q-Value |
|---|---|---|---|---|---|---|---|---|---|
| At the first follow-up | |||||||||
| All subjects (n = 325) | |||||||||
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | Megamonas | 0.341 (0.229, 1.295) | 5.847 (4.782, 11.405) | −0.46 [−0.89, −0.03] | 0.038 | 0.745 |
| Subjects taking dietary fiber ≥ 7.2 g/day (n = 172) | |||||||||
| Firmicutes | 35.830 (24.757, 43.854) | 64.173 (52.077, 72.378) | −0.98 [−1.78, −0.18] | 0.017 | 0.110 | ||||
| Bacteroidetes | Bacteroidia | Bacteroidales | Bacteroidaceae | Bacteroides | 19.104 (9.551, 35.675) | 45.235 (31.419, 64.011) | 1.36 [0.26, 2.46] | 0.017 | 0.393 |
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | (Unknown) | 0.738 (0.279, 2.318) | 8.599 (5.281, 15.283) | −0.43 [−0.79, −0.06] | 0.023 | 0.441 |
| Proteobacteria | Deltaproteobacteria | Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio | 0.037 (0.021, 0.202) | 1.928 (1.433, 4.492) | −0.32 [−0.59, −0.04] | 0.024 | 0.441 |
| Dietary fiber intake: ≥7.2 g/day (n = 172) versus <7.2 g/day (n = 153) | |||||||||
| Fusobacteria | 0.162 (0.097, 0.405) | 4.026 (3.111, 6.368) | −3.27 [−5.68, −0.87] | 0.008 | 0.103 | ||||
| At the second follow-up | |||||||||
| All subjects (n = 301) | |||||||||
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | (Unknown) | 0.644 (0.276, 1.780) | 8.035 (5.257, 13.381) | −0.15 [−0.27, −0.03] | 0.014 | 0.448 |
| Dietary fiber intake: ≥7.2 g/day (n = 149) versus <7.2 g/day (n = 152) | |||||||||
| Actinobacteria | Coriobacteriia | Coriobacteriales | Coriobacteriaceae | Adlercreutzia | 0.001 (0.000, 0.006) | 0.354 (0.000, 0.774) | −0.23 [−0.39, −0.08] | 0.003 | 0.139 |
| Bacteroidetes | Bacteroidia | Bacteroidales | Bacteroidaceae | Bacteroides | 25.017 (8.147, 41.863) | 52.380 (28.945, 70.367) | 7.19 [1.43, 12.94] | 0.015 | 0.249 |
| Bacteroidetes | Bacteroidia | Bacteroidales | Prevotellaceae | Prevotella | 2.865 (1.857, 34.708) | 17.008 (13.671, 62.999) | −10.95 [−18.40, −3.50] | 0.004 | 0.139 |
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | Ruminococcus | 0.272 (0.108, 0.905) | 5.215 (3.287, 9.525) | −2.05 [−3.32, −0.78] | 0.002 | 0.139 |
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | (Unknown) | 0.644 (0.276, 1.780) | 8.035 (5.257, 13.381) | −1.43 [−2.86, −0.01] | 0.050 | 0.330 |
| Proteobacteria | Deltaproteobacteria | Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio | 0.041 (0.021, 0.188) | 2.019 (1.441, 4.341) | −1.81 [−3.07, −0.54] | 0.005 | 0.139 |
| Longitudinal analysis | |||||||||
| Higher-higher (n = 82) versus Lower-lower (n = 80) | |||||||||
| Firmicutes | Clostridia | Clostridiales | Ruminococcaceae | Megamonas | 0.354 (0.237, 0.870) | 5.953 (4.874, 9.340) | −4.42 [−8.33, −0.51] | 0.027 | 0.347 |
| Proteobacteria | Deltaproteobacteria | Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio | 0.041 (0.021, 0.198) | 2.037 (1.454, 4.455) | −2.10 [−3.71, −0.49] | 0.011 | 0.319 |
All taxa listed with p-values less than 0.05; abundance of taxa presented as median (IQR); β coefficients [95%CI] for transformed abundance of taxa with per unit dietary fiber intake (g/day) or as the higher (≥7.2 g/day) versus the lower dietary fiber intake (<7.2 g/day), and adjusted for age, sex, education level, duration of diabetes, intervention status in parent trial, physical activity level, energy intake, fat intake, use of anti-diabetes agents and NSAIDs within six months before stool collection.