Table 3.
Yield of extract (mg/g), cytotoxicity (LC50) against Vero African green monkey kidney cells (mg/mL), minimum inhibitory concentration (MIC; mg/mL), total antifungal activity (TAA; yield/MIC) after 24 h incubation (ml/g), and selectivity indices (SI; LC50/MIC) of the acetone extracts of different plant species and amphotericin B (positive control) against test fungi.
Plant Species |
Yield | LC50 | Candida albicans | Cryptococcus neoformans | Aspergillus fumigatus | Average | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC | TAA | SI | MIC | TAA | SI | MIC | TAA | SI | MIC | TAA | SI | |||
A. altissima | 42 | 0.17 | 0.16 | 269 | 1.12 | 0.31 | 134 | 0.56 | 0.16 | 269 | 1.12 | 0.21 | 224 | 0.93 |
A. artemisiifolia | 101 | 0.02 | 0.16 | 646 | 0.11 | 0.63 | 162 | 0.03 | 1.25 | 81 | 0.01 | 0.68 | 296 | 0.05 |
C. canadensis | 47 | 0.17 | 0.16 | 301 | 1.09 | 0.31 | 150 | 0.55 | 0.63 | 75 | 0.27 | 0.37 | 175 | 0.64 |
D. viscosa | 63 | 0.03 | 0.16 | 403 | 0.22 | 0.31 | 202 | 0.11 | 0.63 | 101 | 0.05 | 0.37 | 235 | 0.13 |
E. annuus | 66 | 0.15 | 0.31 | 211 | 0.46 | 0.31 | 211 | 0.46 | 1.25 | 53 | 0.12 | 0.62 | 158 | 0.35 |
X. strumarium | 57 | 0.001 | 0.23 | 243 | 0.003 | 0.16 | 365 | 0.01 | 0.23 | 243 | 0.003 | 0.21 | 284 | 0.003 |
Average | 0.20 | 346 | 0.50 | 0.34 | 204 | 0.29 | 0.69 | 137 | 0.26 | |||||
Amphotericin B | 8 × 10−3 | 8 × 10−3 | 8 × 10−3 |