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. 2022 Feb 28;18(2):e1010092. doi: 10.1371/journal.pgen.1010092

Fig 7. Cross regulation of Hox genes and the repression of TALE cofactors by EGL-5.

Fig 7

(A) Ectopic expression of lin-39 in DA9 and VA12 but not VD13 and ectopic expression of mab-5 in DA9, VA12, and VD13 in egl-5 mutants. (B) egl-5 expression pattern is not changed by mutations in lin-39. (C) Ectopic expression of egl-5 in cholinergic VB11, DB7, VA11, AS11, and DA8 and GABAergic DD5 and VD10-12 in mab-5 mutants. (D) Derepression of ceh-20 and unc-62 in VD13 neurons in egl-5(u202) mutants. (E) Ectopic expression of ser-2 in VD13 upon the misexpression of the a isoform of unc-62. (F) A summary of cross regulation between egl-5 and mab-5. Cells that show ectopic Hox expression in the mutants of the other Hox gene are in yellow. (G) The model for EGL-5 repressing the VD subtype marker ser-2 in VD13 through repressing anterior Hox gene mab-5 and the Meis cofactor unc-62. Scale bars = 20 μm.