Table 1. A summary of the Hox regulation of neuronal differentiation in the C. elegans nervous system.
| Hox regulation | Reference | ||
|---|---|---|---|
| DA | Motor neuron | LIN-39 and MAB-5 regulate unc-129 in DA2-8; MAB-5 represses mig-13 in DA4-8 and activates ser-2 in DA8; EGL-5 induces glr-1 and itr-1 in DA9 | [9] and this study |
| DB | Motor neuron | LIN-39 and MAB-5 regulate unc-129 in DB2-7 | [9] |
| AS | Motor neuron | MAB-5 induces unc-129 in AS11 | This study |
| VA | Motor neuron | LIN-39 and MAB-5 regulate del-1 in VA3-11; MAB-5 represses mig-13 in VA7-11 and induces flp-18 in VA11; EGL-5 represses del-1 and induces flp-18 and mig-13 in VA12 | [9] and this study |
| VB | Motor neuron | LIN-39 and MAB-5 regulate del-1 in VB4-11 | [9] |
| VC* | Motor neuron | LIN-39 promotes the survival of VC1-6 | [18] |
| VD | Motor neuron | MAB-5 induces ser-2 in VD12; EGL-5 represses ser-2 in VD13 | This study |
| DD | Motor neuron | EGL-5 represses flp-13 in DD6 | This study |
| AVL | Motor neuron | No regulation found | This study |
| AQR | Sensory | LIN-39 regulates gcy-32, gcy-37, and F49H12.4 and the migration of its precursor | This study and [18] |
| PQR | Sensory | MAB-5 regulates the migration of PQR precursor | [20] |
| AIY | Interneuron | No regulation found | This study |
| AVM | Sensory | LIN-39 regulates gcy-37 and the migration of AVM precursor | This study and [18] |
| SDQ | Interneuron | LIN-39 regulates lad-2 and flp-12 in SDQR and acts redundantly with MAB-5 to regulate them in SDQL; LIN-39 and MAB-5 regulate the migration of SDQR and SDQL precursors, respectively | This study and [18, 20] |
| PDE | Sensory | LIN-39 regulates ser-2 and axonal growth | This study |
| PVD | Sensory | LIN-39 regulates ser-2 and F49H12.4 | This study |
| HSN | Motor neuron | EGL-5 regulates tph-1 and kal-1 and controls HSN migration and serotonin production | This study and [8] |
| PDA* | Motor neuron | EGL-5 regulates cog-1 and ace-3/4 and promotes Y-to-PDA transdifferentiation | [24] |
| PDB | Motor neuron | EGL-5 regulates kal-1 | This study |
| DVB* | Motor neuron | EGL-5 regulates flp-10, unc-47, and kal-1 and may promote K-to-DVB transdifferentiation | This study |
| PHB | Sensory | EGL-5 regulates flp-4; EGL-5 regulates srb-6 in ham-1(-) mutants | This study and [25] |
| LUA | Interneuron | No regulation found | This study and [28] |
| PVC* | Interneuron | EGL-5 regulates nmr-1 and glr-1 | [6] |
| PLM | Sensory | EGL-5 regulates mec-3, which activates TRN fate genes | [7] |
| DVA | Interneuron | No regulation found | This study |
| DVC | Interneuron | No regulation found | This study |
| PVR | Interneuron | No regulation found | This study |
| PHC* | Sensory | PHP-3 and NOB-1 regulate ida-1 and dop-1 | This study |
| PLN* | Sensory | PHP-3 and NOB-1 regulate lad-2 and ser-2 | This study |
Asterisks (*) indicate that Hox genes were known to regulate neurogenesis for these neurons or the possible involvement of Hox genes in their generation could not be ruled out.