Table 4.
Non-silent mutations found in AY.127 genes from infected humans and hamsters.
| Amino acid mutation* |
Reference AY.127 genome sequences |
Patient |
Hamster |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1† | 2‡ | 3§ | 4¶ | Shop keeper | Mother | Father | Pet shop A |
Warehouse |
||||||||||||
| 1‖ | 2 | 3 | 4 | 5 | 6 | 7** | 8 | 9 | 10 | 11 | 1 | |||||||||
| S gene | ||||||||||||||||||||
| 21614C→T | Leu18Phe | No | No | No | No | Yes | Yes | Yes | Yes | Yes | .. | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| 21707C→T | His49Tyr | No | No | No | No | Yes | No | No | Yes | No | .. | Yes | No | No | No | No | No | Yes | Yes | No |
| 22842A→G | Asp427Gly | No | No | No | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
| ORF10 gene | ||||||||||||||||||||
| 29670C→T | Thr38Ile | No | No | No | No | No | Yes | Yes | No | Yes | No | No | No | Yes | Yes | Yes | Yes | No | No | Yes |
*
Unique non-silent mutations reproducibility found in both studied human and hamster cases.
†
European AY.127 sequence hCoV 19/Czech Republic/FNHK-Ps-002079/2021|2021-12-23|2022-01-06.
‡
European AY.127 sequence hCoV-19/Czech Republic/UMTM367538/2021|2021-12-09|2022-01-13.
§
European AY.127 sequence hCoV-19/Czech Republic/NRL_16717/2021|2021-11-11|2022-01-14.
¶
European AY.127 sequence hCoV-19/Czech Republic/FNHK-Ps 001677/2021|2021-12-08|2021-12-30.
‖
Representative viral genome that is genetically closest to the one detected in patient 1 (pet shop keeper).
**
Representative viral genome that is genetically closest to the one detected in patients 2 (mother) and 3 (father).