Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 24;12:775132. doi: 10.3389/fonc.2022.775132

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Cui, Xin, Li, Deng and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Butorphanol suppresses the proliferation and migration of osteosarcoma. (A) CCK-8 assay to detect the viability of MG63 and U2OS cells incubated with 0, 5, 10, 20, 40 and 60 μg/ml of butorphanol for 0, 12, 24, 48 h and 72 h ** indicates the 10 μg/ml group versus 0 μg/ml group (p<0.01), ^## indicates the 20 μg/ml group versus 0 μg/ml group (p<0.01), ^&& indicates the 40 μg/ml group versus 0 μg/ml group (p<0.01), and ^$$ indicates the 60 μg/ml group versus 0 μg/ml group (p<0.01). (B) Scratch assay of the migration of MG63 and U2OS cells treated with 10 μg/ml of butorphanol for 24 h (C) Colony formation assay of the proliferation of MG63 and U2OS cells treated with 10 μg/ml of butorphanol. ** indicates p<0.01 and *** indicates p<0.001. (D) Transwell assay of the migration of MG63 and U2OS cells treated with 10 μg/ml of butorphanol for 24 h ** indicates p<0.01, and *** indicates p<0.001.